Butterbur has emerged from folk medicine to clinical validation as both a migraine preventive and an anti-allergy herb. Its petasin compounds inhibit leukotriene and histamine release, reducing allergic rhinitis symptoms comparably to cetirizine in some trials. For migraines, it reduces attack frequency with consistent daily use. Only PA-free (pyrrolizidine alkaloid-free) standardised extracts should be used internally.
rhizome, leaf (PA-free extract only)
standardised extract, capsule
50–75mg PA-free standardised extract twice daily for migraine prevention; follow product guidelines strictly
CRITICAL: Only use PA-free (pyrrolizidine alkaloid-free) certified extracts — raw plant contains hepatotoxic PAs. Avoid in pregnancy and breastfeeding. Avoid in liver disease. Discontinue if jaundice or liver symptoms develop.
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