Japanese knotweed root is exceptionally rich in resveratrol — the same stilbene polyphenol found in red wine — as well as trans-resveratrol and emodin. It has gained considerable attention in Lyme disease herbal protocols for its ability to cross the blood-brain barrier, deliver anti-Borrelial activity, reduce neurological inflammation, and modulate immune response. It is also used for cardiovascular protection and as a potent antioxidant.
root, rhizome
tincture, capsule, decoction, powder
1 tsp dried root decocted 20 min, 2 cups daily; or 20–40 drops tincture 2–3× daily; 500–1000mg standardised extract daily
May thin blood — caution with anticoagulants. Avoid in pregnancy. High emodin content may have a laxative effect in large doses. Source from clean, uncontaminated environments (knotweed accumulates heavy metals).
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